Acetic Anhydride → HCID 178486873, Verbindung

HRID 415017Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 415017
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([OH:13])=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[OH:14].[CH3:15][C:16](OC(C)=O)=[O:17]>N1C=CC=CC=1>[OH:13][C:7]1[C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[C:4]([O:14][C:16](=[O:17])[CH3:15])[CH:5]=2)[N:10]=[CH:9][N:8]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 178486868HCID 178486868, Verbindung

Produkt 1

HCID 178486873HCID 178486873, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 7-Methoxy-quinazoline-4,6-diol (6.2 g, 32.3 mmol), Ac2O (100 mL) and pyridine (10 mL) was heat to 100° C., and stirred for 3 hours. The reaction was then cooled to room temperature and poured to ice water (300 mL). The product was isolated by filtration, washed with water (200 mL) and dried to give 7.61 g (32.4 mmol, 100%) of desired product.

Aufarbeitung

  1. temperatureThe reaction was then cooled to room temperature
  2. customThe product was isolated by filtration
  3. washwashed with water (200 mL)
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ef03563a05fd4561bca314f0573b0d09
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088766B2

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