Acetylpyrazine → N-(2-Amino-phenyl)-4-{[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-methyl}-benzamide

HRID 416271

Reaktionsgleichung

Reaktionsgleichung von HRID 416271
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]2[N:23]=C(C3C=NC=CN=3)C=[CH:20][N:19]=2)=[CH:12][CH:11]=1.N1C=CN=CC=1C(=O)C.[CH3:40][C:41]1[S:42][C:43]([C:47](=O)[CH3:48])=[C:44]([CH3:46])[N:45]=1>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18]2[N:23]=[C:47]([C:43]3[S:42][C:41]([CH3:40])=[N:45][C:44]=3[CH3:46])[CH:48]=[CH:20][N:19]=2)=[CH:12][CH:11]=1

Komponenten

4

Edukt 3

HCID 30914AcetylpyrazineHCID 5208882,4-Dimethyl-5-acetylthiazoleHCID 44570891N-(2-aminophenyl)-4-((4-(pyrazin-2-yl)pyrimidin-2-ylamino)methyl)benzamide

Produkt 1

HCID 58930651N-(2-Amino-phenyl)-4-{[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-methyl}-benzamide

Versuchsvorschrift

Title compound was obtained according to the scheme 6 similarly to the compound 26a (Example 29) using instead of 1-pyrazin-2-yl-ethanone as the starting material 1-(2,4-dimethyl-thiazol-5-yl)-ethanone (Table 11). Characterization of the title compound is provided in the Table 12.

Quellen und Nachweise

ORD-Eintrag
ord-ef4f9cd05f4448979bcd7209c64a4332
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088805B2

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