2-(3-Chloropropoxy)oxane → Formate

Beteiligte Stoffe

Reaktionsschritte

5-Chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide was prepared by an analogous procedure as described in example 15 starting from 245 mg (1.5 equiv.) 2-(3-chloro-propoxy)-tetrahydro-pyran and 360 mg (0.91 mmol) 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.05% formic acid) gave pure 5-chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide as its formate.

Herkunft & Nachweise