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HRID416510

反应详情

EQUATION

反应方程式

HRID 416510 的结构方程式

REACTANTS

反应物

2
结构：ClCCCOC1CCCCO1
HCID254954

未命名化合物

结构：CC(C)N1CCC(NS(=O)(=O)CCNC(=O)c2ccc(Cl)s2)CC1
HCID11990478

未命名化合物

PRODUCTS

生成物

2
结构：O=C[O-]
HCID283

Formic acid, ion(1-)

CHO2-

结构：CC(C)N1CCC(N(CCCOC2CCCCO2)S(=O)(=O)CCNC(=O)c2ccc(Cl)s2)CC1
HCID66624965

未命名化合物

PROCEDURE

实验过程

5-Chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide was prepared by an analogous procedure as described in example 15 starting from 245 mg (1.5 equiv.) 2-(3-chloro-propoxy)-tetrahydro-pyran and 360 mg (0.91 mmol) 5-chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide. Final purification by preparative RP-HPLC (CH3CN/H2O gradient+0.05% formic acid) gave pure 5-chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide as its formate.

WORKUP

后处理

  1. custom5-Chloro-thiophene-2-carboxylic acid (2-{(1-isopropyl-piperidin-4-yl)-[3-(tetrahydro-pyran-2-yloxy)-propyl]-sulfamoyl}-ethyl)-amide was prepared by an analogous procedure
  2. customFinal purification by preparative RP-HPLC (CH3CN/H2O gradient+0.05% formic acid)