Einecs 211-027-4 → 1-Butyl-5,6-dimethyl-3-hydroxy-2-pyridone

HRID 416547Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 416547
[Cl-].[NH+]1C=CC=CC=1.[CH2:8]([N:12]1[C:17]([CH3:18])=[C:16]([CH3:19])[CH:15]=[C:14]([O:20]C)[C:13]1=[O:22])[CH2:9][CH2:10][CH3:11]>C(OCC)C>[CH2:8]([N:12]1[C:17]([CH3:18])=[C:16]([CH3:19])[CH:15]=[C:14]([OH:20])[C:13]1=[O:22])[CH2:9][CH2:10][CH3:11]

Komponenten

4

Edukt 2

HCID 69401Einecs 211-027-4HCID 222665381-Butyl-5,6-dimethyl-3-methoxy-2-pyridone

Produkt 1

HCID 222665251-Butyl-5,6-dimethyl-3-hydroxy-2-pyridoneAusbeute 81,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

Pyridinium chloride (293 mg) was added to 1-butyl-5,6-dimethyl-3-methoxy-2-pyridone (1-004-07) (124 mg), and the reaction mixture was heated with stirring in an oil bath at 200° C. under nitrogen atmosphere. After 30 min, the reaction mixture was dissolved in diethyl ether and water, extracted twice with diethyl ether, washed once with water, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 1-butyl-5,6-dimethyl-3-hydroxy-2-pyridone (1-004-08) (94 mg, 81%, m.p.: 112-116° C.)

Aufarbeitung

  1. temperaturethe reaction mixture was heated
  2. extractionwater, extracted twice with diethyl ether
  3. washwashed once with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bb51cadf374c45c693b83a7fca79fbd8
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088924B2

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