5,6-Dimethyl-2-methoxy-3-nitropyridine → 3-Amino-5,6-dimethyl-2-methoxypyridine
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[C:4]([N+:11]([O-])=O)[C:5]([O:9][CH3:10])=[N:6][C:7]=1[CH3:8]>O1CCCC1.[Pd].CO>[NH2:11][C:4]1[C:5]([O:9][CH3:10])=[N:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=1Komponenten
5
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
5,6-Dimethyl-2-methoxy-3-nitropyridine (1-013-06) (2.56 g) was dissolved in tetrahydrofuran (41 mL), and to the reaction mixture was added a suspension of 5% palladium on carbon (450 mg) in methanol (41 mL), and then the catalytic reduction was carried out. After 3 h, catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 3-amino-5,6-dimethyl-2-methoxypyridine (1-013-07) (2.096 g, 97.9%, m.p.: 56-58° C.) as a blackish brown crystal.
Aufarbeitung
- additionto the reaction mixture was added
- filtrationcatalyst was filtered off
- customthe filtrate was evaporated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-54b51f51fd3e443fab7607d70d5a6ded
- Quelldatensatz
- uspto-grants-2012_01
- Patentnummer
- US08088924B2
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