3-Ethylpyridine → 3-Ethylpyridine

HRID 417795

Reaktionsgleichung

Reaktionsgleichung von HRID 417795
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6](=O)[N:7](C2C=CC=CC=2)[CH:8]=1)[CH3:2].[CH2:16]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:17]>C(O)(=O)CCCCCCC/C=C\CCCCCCCC>[NH2:20][C:6]1[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][N:7]=1.[CH2:16]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:17]

Komponenten

5

Edukt 2

HCID 108233-EthylpyridineHCID 101303775-ETHYL-1-PHENYL-1H-PYRIDIN-2-ONE

Produkt 2

HCID 108233-EthylpyridineHCID 98127775-Ethylpyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 445639Oleic AcidKatalysator

Versuchsvorschrift

In said first reaction scheme, we have found that 5-ethyl-1-phenyl-2-(1H)-pyridone can be made from 3-ethyl pyridine (available from Sigma-Aldrich Corporation, St. Louis, Mo.) which is reacted with NaNH2 in presence of a small amount of oleic acid as a catalyst to speed up the reaction. A general reaction scheme for obtaining 2-amino-5-ethyl pyridine isomer from 3-ethylpyridine is provided in U.S. Pat. No. 5,003,069 to McGill et al, “Chichibabin Reaction,” at Example 12. U.S. Pat. No. 5,003,069 is herein incorporated by reference as if fully set forth herein. In this reaction 3-ethyl pyridine (I) is converted to 2-amino-5-ethylpyridine (II) as well as 2-amino-3-ethylpyridine(III).

Aufarbeitung

  1. customIn said first reaction scheme, we
  2. customthe reaction
  3. customA general reaction scheme

Quellen und Nachweise

ORD-Eintrag
ord-a91e2bdc326949c5965b6b68c6e11de4
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093210B2

Verknüpfte Notizen

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