Diisopropylethylamine → 1,1-Dimethylethyl 4-{[2-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

HRID 418288

Reaktionsgleichung

Reaktionsgleichung von HRID 418288
[N:1]1([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.CCN(C(C)C)C(C)C.[Br:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][C:25]=1[S:34](Cl)(=[O:36])=[O:35]>ClCCl>[Br:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([F:32])([F:31])[F:33])=[CH:26][C:25]=1[S:34]([N:4]1[CH2:5][CH2:6][N:1]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:2][CH2:3]1)(=[O:36])=[O:35]

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 27786132-Bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride

Produkt 1

HCID 666496401,1-Dimethylethyl 4-{[2-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1,1-dimethylethyl 1-piperazinecarboxylate (1 g, 5.37 mmol) in dichloromethane (40 ml) was added DIPEA (1.969 ml, 11.28 mmol) and then 2-bromo-5-(trifluoromethyl)benzenesulfonyl chloride (1.737 g, 5.37 mmol). The mixture was stirred for 1 h 20 at room temperature before it was washed with water (50 ml), dried on a phase separation cartridge and concentrated under vacuum.

Aufarbeitung

  1. washwas washed with water (50 ml)
  2. customdried on a phase separation cartridge
  3. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-771aa05f240b40c19bdd858f5022e5b2
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093249B2

Verknüpfte Notizen

Wird geladen…