Glycerol → Bupivacaine (USAN:INN:BAN)

HRID 41862

Reaktionsgleichung

Reaktionsgleichung von HRID 41862
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.OCC(CO)O>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 753GlycerolHCID 64737Bupivacaine Hydrochloride

Produkt 1

HCID 2474Bupivacaine (USAN:INN:BAN)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A composition suitable for administration in vaginal suppository form 1a prepared by weighing 2 mg of finely divided polynucleotide medicinal substance into a tared container, adding 10 ml of 0.5% bupivacaine HCl in purified water, to make a total of 10 g, and dissolving or mixing depending on the solubility of the medicinal substance; 70 g of glycerin is added and mixed; 20 g of granular gelatin is then added and the composition heated carefully on a steam bath until the gelatin is dissolved. The melted mixture is poured into chilled molds to yield 20 vaginal suppositories of 6 grams each containing 100 mcg of polynucleotide medicinal substance in admixture with 2.5 mg bupivacaine.

Aufarbeitung

  1. dissolutiondissolving
  2. additionmixing
  3. additionmixed
  4. addition20 g of granular gelatin is then added
  5. temperaturethe composition heated carefully on a steam bath until the gelatin
  6. dissolutionis dissolved
  7. additionThe melted mixture is poured
  8. temperatureinto chilled molds

Quellen und Nachweise

ORD-Eintrag
ord-4f0a15a511904dc2877b11674f51e089
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536145B2

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