2-Chloro-5-nitro-3-(trifluoromethyl)pyridine → 6-Chloro-5-(trifluoromethyl)pyridin-3-amine

HRID 41976Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 41976
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N+:12]([O-])=O)=[CH:4][N:3]=1>C(OCC)(=O)C.[Zn+2].[Br-].[Br-]>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([NH2:12])=[CH:6][C:7]=1[C:8]([F:11])([F:9])[F:10]

Komponenten

4

Edukt 1

HCID 38491402-Chloro-5-nitro-3-(trifluoromethyl)pyridine

Produkt 1

HCID 135322446-Chloro-5-(trifluoromethyl)pyridin-3-amineAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 10421208Zinc bromideKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (5.25 mmol, 1.19 g), ZnBr2 (1.05 mmol, 0.200 g) and 5% Pt (C) (1.58 mmol, 0.31 g) in ethyl acetate (50 ml) was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off and the solid was washed with warmed ethanol. The solvent was evaporated affording the expected product (0.95 g, yield 92%).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washthe solid was washed with warmed ethanol
  3. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-dd5d5aedb746487fad31455fd2cacb7e
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536165B2

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