Oxalyl chloride → (S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate

HRID 419769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 419769
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@@:12]1([CH3:19])[C:16](O)=[O:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:23])=O>ClCCl.CN(C)C=O>[Cl:23][C:16]([C@:12]1([CH3:19])[CH2:13][CH2:14][CH2:15][N:11]1[C:9]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10])=[O:17]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 18604408HCID 18604408, Verbindung

Produkt 1

HCID 86643491(S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of (S)-1-(benzyloxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid (1.50 g) in dichloromethane (30 mL) was treated with oxalyl chloride (0.65 mL) and 3 drops of N,N-dimethylformamide at ambient temperature for 1.5 hours. The mixture was concentrated and the crude material used in the next step without further purification.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. customthe crude material used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-377d50e1d6664017ba4a218ebd63499c
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093396B2

Notizen zur Reaktion

Wird geladen…