4-Chlorophenyl isothiocyanate → Ethyl 1-{[(4-chlorophenyl)amino]thioxomethyl}piperidine-4-carboxylate

HRID 419845

Reaktionsgleichung

Reaktionsgleichung von HRID 419845
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[NH:11]1[CH2:21][CH2:20][CH:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:13][CH2:12]1>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:11]2[CH2:21][CH2:20][CH:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:13][CH2:12]2)=[S:10])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 164804-Chlorophenyl isothiocyanateHCID 70770Ethyl 4-piperidinecarboxylate

Produkt 1

HCID 4232750Ethyl 1-{[(4-chlorophenyl)amino]thioxomethyl}piperidine-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 4-chlorophenyl isothiocyanate (3.5 g, 20.7 mmol), and ethyl isonipecotate (3.19 mL, 20.7 mmol) in dichloromethane (30 mL) was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, the residue was triturated with ether and the resulting solid was filtered off and dried to afford the title compound as a white solid, 6.27 g.

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe residue was triturated with ether
  3. filtrationthe resulting solid was filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-76c52aa985ef4e53822637a1a51a0ad5
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093400B2

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