2-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrile → 3-Amino-2-[(2-hydroxyethyl)amino]benzonitrile

HRID 419935Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 419935
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[C:12]([N+:13]([O-])=O)=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8].[H][H]>[Pd].CO>[NH2:13][C:12]1[C:5]([NH:4][CH2:3][CH2:2][OH:1])=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8]

Komponenten

5

Edukt 2

HCID 114470952-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrileHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 582984983-Amino-2-[(2-hydroxyethyl)amino]benzonitrileAusbeute 106,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Methanol (500 ml) and Pd/activated charcoal 5% (wet, 3.45 g) are added to 2-[(2-hydroxyethyl)amino]-3-nitrobenzonitrile (69 g, 0.333 mol). The suspension is shaken in a Parr apparatus under 20 psi pressure of hydrogen for 1 hour. The mixture is then filtered on Celite and evaporated to dryness to give the desired material (62.7 g). This product is used in the next step without further purification.

Aufarbeitung

  1. filtrationThe mixture is then filtered on Celite
  2. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-1e16d104712e47599c2f1eab463aeca0
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093402B2

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