4-(2,2,2-Trifluoroethoxy)aniline → 2-(4-(2,2,2-Trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione

HRID 420662

Reaktionsgleichung

Reaktionsgleichung von HRID 420662
C(O[C:4]([C:6]1([CH2:13][CH2:14]OC)[CH2:11][CH2:10][NH:9][C:8](=[O:12])[CH2:7]1)=[O:5])C.[Cl-].C[Al+]C.[F:21][C:22]([F:33])([F:32])[CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][CH:26]=1>>[F:21][C:22]([F:32])([F:33])[CH2:23][O:24][C:25]1[CH:26]=[CH:27][C:28]([N:31]2[CH2:14][CH2:13][C:6]3([CH2:11][CH2:10][NH:9][C:8](=[O:12])[CH2:7]3)[C:4]2=[O:5])=[CH:29][CH:30]=1

Komponenten

4

Edukt 3

HCID 27771194-(2,2,2-Trifluoroethoxy)anilineHCID 16686359Dimethylalumanylium chlorideHCID 584784144-(2-Methoxy-ethyl)-2-oxo-piperidine-4-carboxylic acid ethyl ester

Produkt 1

HCID 584784102-(4-(2,2,2-Trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione

Versuchsvorschrift

This material was prepared as a light brown solid (0.685 g) in analogy to example 1 step D) from 4-(2-methoxy-ethyl)-2-oxo-piperidine-4-carboxylic acid ethyl ester (1 g), dimethylaluminium chloride (1 M in hexane, 17.4 ml) and 4-(2,2,2-trifluoro-ethoxy)-phenylamine (1.25 g). MS (ESI): 343.12 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-861839c7ddf8486296267e5074b80b93
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08097634B2

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