2-Amino-6-methoxy-3-nitropyridine → 2,3-Diamino-6-methoxypyridine

HRID 420696

Reaktionsgleichung

Reaktionsgleichung von HRID 420696
[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([N+:10]([O-])=O)=[CH:5][CH:4]=1.[H][H]>CCO.[Pd]>[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([NH2:10])=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 38524282-Amino-6-methoxy-3-nitropyridineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 30239202,3-Diamino-6-methoxypyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

6-(Methyloxy)-3-nitro-2-pyridinamine (26 g, 129 mmol) was suspended in EtOH (500 ml) at room temperature under argon and then treated with palladium on carbon (15 g, 14.10 mmol) (10% paste). The reaction was stirred under 1 atmosphere of hydrogen overnight. The reaction was filtered through a Celite pad and the pad washed with EtOH (500 ml). EtOH was evaporated to afford the product as a purple oil (20.68 g, slightly impure).

Aufarbeitung

  1. filtrationThe reaction was filtered through a Celite pad
  2. washthe pad washed with EtOH (500 ml)
  3. customEtOH was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-88a8f48586f44d03bb48499e5776ae34
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08097628B2

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