Citric Acid → Quetiapine Citrate

HRID 421569

Reaktionsgleichung

Reaktionsgleichung von HRID 421569
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]([OH:40])(=[O:39])[CH2:29][C:30]([CH2:35][C:36]([OH:38])=[O:37])([C:32]([OH:34])=[O:33])[OH:31]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]([O-:40])(=[O:39])[CH2:29][C:30]([CH2:35][C:36]([O-:38])=[O:37])([C:32]([O-:34])=[O:33])[OH:31]

Komponenten

4

Edukt 2

HCID 311Citric AcidHCID 5002Quetiapine

Produkt 1

HCID 86647095Quetiapine Citrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of citric acid (1.1 g) at 30 to 35° C. The resulting mass was heated at reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.95 g).

Aufarbeitung

  1. temperatureThe resulting mass was heated
  2. temperatureat reflux
  3. temperaturemaintained for 30 minutes
  4. distillationThis was followed by the distillation of acetone
  5. customobtained solid
  6. customwas further dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4a3066286e1c48888a8b6017ba2bc218
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101597B2

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