9-ethyl-2-(methylamino)-9H-pyrido[2,3-b]indole-3-carboxamide → tert-butyl{(1S)-2-[3-(aminocarbonyl)-2-(methylamino)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	9-ethyl-2-(methylamino)-9H-pyrido[2,3-b]indole-3-carboxamide	HCID 24900932	—
Edukt	tert-butyl {(1S)-2-[2-amino-3-(aminocarbonyl)-9h-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate	HCID 59513639	—
Produkt	tert-butyl{(1S)-2-[3-(aminocarbonyl)-2-(methylamino)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate	HCID 59513645	89%

Reaktionsschritte

tert-butyl {(1S)-2-[2-amino-3-(aminocarbonyl)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate (xvi-b, 20 mg, 0.052 mmol) was alkylated according to procedure detailed in the preparation of 48, to afford tert-butyl {(1S)-2-[3-(aminocarbonyl)-2-(methylamino)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate (xxxii-a, 20 mg, 89%). NH4OAc QC conditions. M+H=398.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08101604B2
Quelldatensatz	uspto-grants-2012_01
ORD ID	ord-56ac3522643645e9b4b88438c65530fa
Quellennotiz	uspto-grants-2012_01