Sodium Iodide → 1-Iodo-3-methoxy-5-methylbenzene

Cu(I)I (0.05 g, 0.25 mmol) and NaI (1.49 g, 10 mmol) were added to an oven dried sealed tube and the tube sealed with a rubber septum and flushed with a stream of nitrogen for 15 min. Anhydrous dioxane (5 mL), N,N′-dimethyl ethylenediamine (0.055 mL, 0.50 mmol) and 1-bromo-3-methoxy-5-methylbenzene (1) (1.0 g, 5.0 mmol) were added via a syringe with vigorous stirring under a stream of nitrogen at room temperature. The rubber septum was replaced with the Teflon cap and the sealed tube was heated at 110° C. in an oil bath for 18 h. The reaction was allowed to cool to room temperature and then quenched with a saturated aqueous solution of ammonium chloride. The reaction mixture was extracted with CH2Cl2. The organic layer was washed with water, and then concentrated to dryness to give 1-iodo-3-methoxy-5-methylbenzene (2) (1.05 g, 87% yield) as a pale yellow oil.

1. customdried
2. customsealed tube
3. customthe tube sealed with a rubber septum
4. customflushed with a stream of nitrogen for 15 min
5. customcap
6. temperaturethe sealed tube was heated at 110° C. in an oil bath for 18 h
7. temperatureto cool to room temperature
8. customquenched with a saturated aqueous solution of ammonium chloride
9. extractionThe reaction mixture was extracted with CH2Cl2
10. washThe organic layer was washed with water
11. concentrationconcentrated to dryness

ORD-Eintrag

ord-73235beca452445b8809edfb891be59d

Quelldatensatz

uspto-grants-2012_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08101605B2