2,4-Dichloropyrimidine → 2-Chloro-4-(4-phenylbut-1-ynyl)pyrimidine
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH2:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:10][C:11]#[CH:12]>>[Cl:1][C:2]1[N:7]=[C:6]([C:12]#[C:11][CH2:10][CH2:9][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[CH:4][N:3]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared in accordance with the general method of Example 1, from 2,4-dichloropyrimidine (250 mg, 1.68 mmol) and 1-(but-3-ynyl)benzene (218 mg, 1.68 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1) to yield 280 mg (1.15 mmol, 69%) of 2-chloro-4-(4-phenylbut-1-ynyl)pyrimidine as a brown oil.
Aufarbeitung
- customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1)
Quellen und Nachweise
- ORD-Eintrag
- ord-76390baba8454e949e6a2c9c9b175302
- Quelldatensatz
- uspto-grants-2012_01
- Patentnummer
- US08101637B2
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