Hydrazine hydrate (1:1) → 3-(1H-Indol-3-yl)propanohydrazide

HRID 422834Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 422834
C([O:3][C:4](=O)[CH2:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][CH:8]=1)C.O.[NH2:18][NH2:19]>C(O)C>[NH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([CH2:6][CH2:5][C:4]([NH:18][NH2:19])=[O:3])=[CH:8]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 225390Ethyl 3-(1h-indol-3-yl)propanoate

Produkt 1

HCID 2305803-(1H-Indol-3-yl)propanohydrazideAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3-(1H-Indol-3-yl)-propionic acid ethyl ester (4.30 g, 1 eq) and hydrazine hydrate (˜9.6 ml, 10 eq) in ethanol (70 ml) is heated at 60° C. overnight. The reaction mixture is concentrated under reduced pressure and diluted with methylene chloride. The new organic solution is washed with water, dried over MgSO4, filtered and evaporated to dryness, to afford the title compound as white solid (3.9 g, 98% yield), which is used as such for the next step.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additiondiluted with methylene chloride
  3. washThe new organic solution is washed with water
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-14013f02603e48cd9cdf138b5dea52dd
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101649B2

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