Urea → 2,2-Dimethylsuccinimide

HRID 423166Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 423166
[CH3:1][C:2]([CH3:10])([C:7](O)=[O:8])[CH2:3][C:4](O)=[O:5].[NH2:11]C(N)=O>O>[CH3:1][C:2]1([CH3:10])[CH2:3][C:4](=[O:5])[NH:11][C:7]1=[O:8]

Komponenten

4

Edukt 2

HCID 1176UreaHCID 117012,2-Dimethylsuccinic acid

Produkt 1

HCID 2256782,2-DimethylsuccinimideAusbeute 89,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

10 g of 3,3-dimethyl succinic acid and 102.7 g of urea were mixed and stirred at 160° C. for 10 hours. Then water was added to the reaction mixture which was cooled to about 100° C., and further cooled to about room temperature, then extracted with ethyl acetated three times. The organic layers were joined, washed with saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.8 g of 3,3-dimethyl-2,5-pyrrolidine dion.

Aufarbeitung

  1. temperaturewas cooled to about 100° C.
  2. temperaturefurther cooled to about room temperature
  3. extractionextracted with ethyl
  4. washwashed with saturated aqueous solution of sodium chloride
  5. dry with materialdried with anhydrous magnesium sulfate
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-afc57db5b74d4b78be92e6daa89e28b4
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101753B2

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