Methyl Vanillate → Methyl 4-hydroxy-3-iodo-5-methoxybenzoate

HRID 423259Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 423259
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([O:11][CH3:12])[CH:5]=1.[I:14]N1C(=O)CCC1=O>O1CCCC1>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:5]=[C:6]([O:11][CH3:12])[C:7]([OH:10])=[C:8]([I:14])[CH:9]=1

Komponenten

4

Edukt 2

HCID 19844Methyl VanillateHCID 120273N-Iodosuccinimide

Produkt 1

HCID 53426739Methyl 4-hydroxy-3-iodo-5-methoxybenzoateAusbeute 113,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4-hydroxy-3-methoxybenzoic acid methyl ester (5.0 g) in tetrahydrofuran (20 mL) was added N-iodosuccinimide (6.17 g) at 0° C., and the mixture was stirred for 1 hour. The precipitated solid was filtered, washed with water, and dried to give the title compound (9.60 g).

Aufarbeitung

  1. filtrationThe precipitated solid was filtered
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-91f5d4f170584cc5abefa9ba12bcba63
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101774B2

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