Sodium Carbonate → HCID 178471833, Verbindung

HRID 423336

Reaktionsgleichung

Reaktionsgleichung von HRID 423336
[C:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])#[N:2].[NH2:19][OH:20].Cl.C([O-])([O-])=O.[Na+].[Na+]>CCO>[OH:20][NH:19][C:1](=[NH:2])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochloride2×HCID 59318406Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate

Produkt 1

HCID 178471833HCID 178471833, VerbindungAusbeute 103,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate (D54) (3.44 g), NH2OH.HCl (1.97 g) and Na2CO3 (5.96 g) were dissolved in EtOH (75 ml). This mixture was heated at 50° C. overnight. A further portion of NH2OH.HCl (985 mg) was added and the mixture stirred at 70° C. overnight. The reaction mixture was then filtered and evaporated to give the title compound (4.06 g). MS (ES): C14H17N3O3 requires 275; found 276 (MH+)

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-dd893dce617e4ced8e0a263297264b48
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101775B2

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