Water → 2-(4-Chlorophenyl)-6H,7H-thieno[2,3-c]pyridin-7-one

HRID 423389Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 423389
FC(F)(F)S(O)(=O)=O.O=[CH:10][CH2:11][NH:12][C:13]([C:15]1[S:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[CH:18][CH:19]=1)=[O:14].O>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([C:17]2[S:16][C:15]3[C:13](=[O:14])[NH:12][CH:11]=[CH:10][C:19]=3[CH:18]=2)=[CH:21][CH:22]=1

Komponenten

4

Edukt 3

HCID 962WaterHCID 62406Trifluoromethanesulfonic acidHCID 866292045-(4-Chlorophenyl)-thiophene-2-carboxylic acid (2-oxoethyl)amide

Produkt 1

HCID 576495192-(4-Chlorophenyl)-6H,7H-thieno[2,3-c]pyridin-7-oneAusbeute 100 %

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

Add trifluoromethane sulfonic acid (3 mL, 0.03 mol) and 5-(4-chlorophenyl)-thiophene-2-carboxylic acid (2-oxoethyl) amide (1 g, 0.004 mol) to a 25 mL three-necked round bottom flask equipped with a stir bar, Dean-Stark trap, nitrogen inlet/outlet, and thermocouple. Heat the reaction mixture to 95° C. for 2 h, then cool to 40° C., and pour onto cold water (20 mL, 1.11 mol). Stir the mixture for 10 min. Filter the resulting slurry and rinse the solids with water (100 mL). Dry to afford crude 2-(4-chlorophenyl)-6H-thieno[2,3-c]pyridine-7-one (0.95 g, 0.004 mol) as a brown solid. LC-MS/ES m/z (35Cl) 262 [M+H]+.

Aufarbeitung

  1. customequipped with a stir bar
  2. temperaturecool to 40° C.
  3. filtrationFilter the resulting slurry
  4. washrinse the solids with water (100 mL)
  5. customDry

Quellen und Nachweise

ORD-Eintrag
ord-8883115bec95413286807a855a70b050
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101764B2

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