Triphenylphosphine → 2-(4-Bromophenoxy)propyl 2-methylacrylate

HRID 424309

Reaktionsgleichung

Reaktionsgleichung von HRID 424309
O[C:2]1[CH:7]=[CH:6][C:5](O)=[C:4]([Br:9])[CH:3]=1.[CH3:10][C:11](=[CH2:19])[C:12]([O:14][CH2:15][CH:16]([OH:18])[CH3:17])=[O:13].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1COCC1>[CH3:19][C:11](=[CH2:10])[C:12]([O:14][CH2:15][CH:16]([O:18][C:7]1[CH:6]=[CH:5][C:4]([Br:9])=[CH:3][CH:2]=1)[CH3:17])=[O:13]

Komponenten

6

Edukt 4

HCID 11776TriphenylphosphineHCID 135392-Hydroxypropyl methacrylateHCID 685022-Bromo-1,4-benzenediolHCID 5363146Diisopropyl azodicarboxylate

Produkt 1

HCID 590050162-(4-Bromophenoxy)propyl 2-methylacrylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Following the same preparation procedure of Example 2, the reaction was carried out with 4-hydroxy bromophenol (4 g), 2-hydroxypropyl 2-methylacrylate (3.33 g), triphenyl phosphine (6.06 g) and DIAD (4.69 g) in 50 ml of THF to give after chromatography purification pure 2-(4-bromophenoxy)propyl 2-methylacrylate as pale yellow oil.

Aufarbeitung

  1. customthe same preparation procedure of Example 2
  2. customto give
  3. customafter chromatography purification pure 2-(4-bromophenoxy)propyl 2-methylacrylate as pale yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-50bf399bb55646d6837673bbf30e7dea
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08105662B2

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