Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide

HRID 4247

Reaktionsgleichung

Reaktionsgleichung von HRID 4247
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 178418324HCID 178418324, Verbindung

Produkt 1

HCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of 42 g (0.5 mol) of cyanoguanidine ("dicyanodiamide") and 50 g (0.5 mol) of 2,4-pentanedione ("acetylacetone") is heated to 120° C. for 15 hours. The reaction mixture is then cooled, after which 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product obtained in crystalline form during this procedure is isolated by filtering it off under suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.

Aufarbeitung

  1. temperatureThe reaction mixture is then cooled
  2. customThe product obtained in crystalline form during this procedure
  3. customis isolated
  4. filtrationby filtering it off under suction

Quellen und Nachweise

ORD-Eintrag
ord-337e60123b3b4db0a8dbe09ecff88ae9
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04725303

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