Sulfamic Acid → 2-Methoxy-5-methylsulfanilic acid

HRID 4252

Reaktionsgleichung

Reaktionsgleichung von HRID 4252
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:7]([CH3:10])=[CH:8][CH:9]=1)[NH2:6].[S:11](=[O:15])(=[O:14])([OH:13])N>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:6])[C:7]([CH3:10])=[CH:8][C:9]=1[S:11]([OH:15])(=[O:14])=[O:13]

Komponenten

4

Edukt 2

HCID 5987Sulfamic AcidHCID 995005-Methoxy-o-toluidine

Produkt 1

HCID 201521062-Methoxy-5-methylsulfanilic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

23.1 g of 3-methoxy-6-methylaniline and 16.4 g of sulfamic acid were put into a 100 ml egg-plant type flask and the mixture was heated to temperature of from 150° to 160° C. and maintained thereat for 2 hours. Acetonitrile was added to the reaction mixture and the crystals thus deposited were collected. The crystals were dissolved in an aqueous solution of sodium hydroxide, the solution was filtered and acidified with hydrochloric acid, and the crystals thus deposited were collected by filtration.

Aufarbeitung

  1. temperaturethe mixture was heated to temperature of from 150° to 160° C.
  2. temperaturemaintained
  3. customthe crystals thus deposited were collected
  4. dissolutionThe crystals were dissolved in an aqueous solution of sodium hydroxide
  5. filtrationthe solution was filtered
  6. filtrationthe crystals thus deposited were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-10a5e567c3634c778989865c564fb6c3
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04725531

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