Methanol → Methyl 4-bromo-3-fluorobenzeneacetate

HRID 425329Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 425329
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#N)=[CH:4][C:3]=1[F:11].S(=O)(=O)(O)O.[OH2:17].[CH3:18][OH:19]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:19][CH3:18])=[O:17])=[CH:4][C:3]=1[F:11]

Komponenten

5

Edukt 4

HCID 887MethanolHCID 962WaterHCID 1118Sulfuric AcidHCID 116009532-(4-Bromo-3-fluorophenyl)acetonitrile

Produkt 1

HCID 71265948Methyl 4-bromo-3-fluorobenzeneacetate

Versuchsvorschrift

(4-bromo-3-fluorophenyl)acetonitrile (40 g, 0.18 mol) was dissolved in 120 mL methanol, and 65 mL concentrated sulfuric acid were added. After heating at reflux overnight, the reaction mixture was cooled, and poured into 600 mL water, and the product was extracted with CH2Cl2. The combined extracts were washed with 10% sodium carbonate solution, dried, and concentrated to afford methyl (4-bromo-3-fluorophenyl)acetate.

Aufarbeitung

  1. temperatureAfter heating
  2. temperatureat reflux overnight
  3. temperaturethe reaction mixture was cooled
  4. extractionthe product was extracted with CH2Cl2
  5. washThe combined extracts were washed with 10% sodium carbonate solution
  6. customdried
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c486df2e7ae841448520cfd8662d0b6a
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08106070B2

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