HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,1-Dichloroethane → 2-(cyclohexylamino)-6-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,1-Dichloroethane | HCID 6365 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one | HCID 33699394 | — |
| Edukt | 2-(Cyclohexylamino)-6-fluoronicotinic acid | HCID 66703826 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 2-(cyclohexylamino)-6-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide | HCID 66703873 | — |
Reaktionsschritte
HATU was added to a dichloroethane solution of 2-(cyclohexylamino)-6-fluoronicotinic acid and triethylamine. After 30 minutes of stirring at room temperature, 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one was added thereto. The reaction liquid was stirred overnight at room temperature and then hearted under reflux for 3 hours. By post-treating the reaction liquid, 2-(cyclohexylamino)-6-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08106190B2 |
| Quelldatensatz | uspto-grants-2012_01 |
| ORD ID | ord-77eb0c87536246de8af8a5379615cd1e |
| Quellennotiz | uspto-grants-2012_01 |