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HRID425988

反应详情

EQUATION

反应方程式

HRID 425988 的结构方程式

REACTANTS

反应物

4
结构：CC(Cl)Cl
HCID6365

1,1-Dichloroethane

C2H4Cl2

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：CN1C(=O)CCc2ccc(N)cc21
HCID33699394

未命名化合物

结构：O=C(O)c1ccc(F)nc1NC1CCCCC1
HCID66703826

未命名化合物

PRODUCTS

生成物

1
结构：CN1C(=O)CCc2ccc(NC(=O)c3ccc(F)nc3NC3CCCCC3)cc21
HCID66703873

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

HATU was added to a dichloroethane solution of 2-(cyclohexylamino)-6-fluoronicotinic acid and triethylamine. After 30 minutes of stirring at room temperature, 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one was added thereto. The reaction liquid was stirred overnight at room temperature and then hearted under reflux for 3 hours. By post-treating the reaction liquid, 2-(cyclohexylamino)-6-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide was obtained.

WORKUP

后处理

  1. customThe reaction liquid
  2. stirringwas stirred overnight at room temperature
  3. temperatureunder reflux for 3 hours
  4. additionBy post-treating
  5. customthe reaction liquid