Butylamine → 2-[4-(4-Chlorophenoxy-methyl)-phenoxy]-propionic acid n-butylamide

HRID 426440Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 426440
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][C:8]2[CH:20]=[CH:19][C:11]([O:12][CH:13]([CH3:18])[C:14]([O:16]C)=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:23]([NH2:27])[CH2:24][CH2:25][CH3:26]>CO>[CH2:23]([NH:27][C:14](=[O:16])[CH:13]([O:12][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][O:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:22][CH:21]=2)=[CH:20][CH:19]=1)[CH3:18])[CH2:24][CH2:25][CH3:26]

Komponenten

4

Edukt 2

HCID 8007ButylamineHCID 19834514Methyl 2-[4-(4-Chlorophenoxy-methyl)-phenoxy]-propionate

Produkt 1

HCID 203908402-[4-(4-Chlorophenoxy-methyl)-phenoxy]-propionic acid n-butylamideAusbeute 39 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6.4 gm of methyl 2-[4-(4-chlorophenoxy-methyl)-phenoxy]-propionate were dissolved in 60 ml of methanol, 6.0 gm of n-butylamine were added to the solution, and the mixture was heated in an autoclave for 4 hours at a pressure of 15-16 atmospheres gauge. After cooling, the solvent was distilled off in vacuo, and the residue was recrystallized from ethanol, yielding 2.8 gm (39% of theory) of the amide named in the heading, which had a melting point of 98° C.

Aufarbeitung

  1. temperaturethe mixture was heated in an autoclave for 4 hours at a pressure of 15-16 atmospheres gauge
  2. temperatureAfter cooling
  3. distillationthe solvent was distilled off in vacuo
  4. customthe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-9f28af55576242cfb7408727fabcfc6e
Quelldatensatz
uspto-grants-1979_10
Patentnummer
US04169720

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