Ethylene Glycol → 2-(2,3,6-Trifluorophenoxy)ethanol

HRID 426745

Reaktionsgleichung

Reaktionsgleichung von HRID 426745
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([F:9])[C:3]=1F.Br.[Na].[CH2:13]([OH:16])[CH2:14][OH:15].Cl>O>[F:9][C:4]1[C:5]([F:8])=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[O:15][CH2:14][CH2:13][OH:16]

Komponenten

6

Edukt 4

HCID 174Ethylene GlycolHCID 313Hydrochloric AcidHCID 110841,2,3,4-TetrafluorobenzeneHCID 86736672Sodium hydrobromide

Produkt 1

HCID 27779442-(2,3,6-Trifluorophenoxy)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1,2,3,4-Tetrafluorobenzene (67.7 g), sodium hydrobromide (20.8 g), and 200 ml of ethyleneglycol are refluxed with good stirring for 3 hours. The reaction mixture is poured into water (800 ml), acidified with 10% hydrochloric acid and then extracted with ether. The ether is washed with dilute sodium hydroxide and water, and then distilled under vacuum to give 2-(2,3,6-trifluorophenoxy) ethanol), b.p. about 100° at 15 min.

Aufarbeitung

  1. extractionextracted with ether
  2. washThe ether is washed with dilute sodium hydroxide and water
  3. distillationdistilled under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-bf5deb0662904b37b672112f98f4d1b2
Quelldatensatz
uspto-grants-1979_10
Patentnummer
US04171359

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