Diazomethane → 4-Nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole

HRID 427223

Reaktionsgleichung

Reaktionsgleichung von HRID 427223
[N+:1]([C:4]1[C:12]2[N:11]=[C:10]([C:13]3[O:17][C:16]([P:18]([O:23][CH2:24][CH3:25])([O:20][CH2:21][CH3:22])=[O:19])=[CH:15][CH:14]=3)[N:9]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:8]=2[C:7]([CH:30]=[CH2:31])=[CH:6][C:5]=1[F:32])([O-:3])=[O:2].[N+](=[CH2:35])=[N-]>CCOCC.CC([O-])=O.CC([O-])=O.[Pd+2]>[N+:1]([C:4]1[C:12]2[N:11]=[C:10]([C:13]3[O:17][C:16]([P:18]([O:23][CH2:24][CH3:25])([O:20][CH2:21][CH3:22])=[O:19])=[CH:15][CH:14]=3)[N:9]([CH2:26][CH:27]([CH3:28])[CH3:29])[C:8]=2[C:7]([CH:30]2[CH2:35][CH2:31]2)=[CH:6][C:5]=1[F:32])([O-:3])=[O:2]

Komponenten

5

Edukt 2

HCID 9550DiazomethaneHCID 544096674-Nitro-7-vinyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole

Produkt 1

HCID 539815924-Nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 167845palladium(II) acetateKatalysatorHCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a suspension of 1.0 mmol of 4-nitro-7-vinyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole and 0.1 mmol of Pd(OAc)2 in 8 mL of ether was added an ether solution of diazomethane(generated from 3.0 g of 1-methyl-3-nitro-1-nitrosoguanidine) at 0° C. After stirring at rt 20 h. solvent was removed and the residue was subjected to chromatography to give 4-nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole.

Aufarbeitung

  1. customwas removed

Quellen und Nachweise

ORD-Eintrag
ord-58964d07bdf049ab9560f3acc0364d62
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06312662B1

Verknüpfte Notizen

Wird geladen…