Methyl 6-amino-5-nitropyridine-3-carboxylate → Methyl 5,6-diaminopyridine-3-carboxylate

HRID 427498Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 427498
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[H][H]>[Pd].CO>[NH2:12][C:11]1[C:2]([NH2:1])=[N:3][CH:4]=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

Komponenten

5

Edukt 2

HCID 13768248Methyl 6-amino-5-nitropyridine-3-carboxylateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 9920476Methyl 5,6-diaminopyridine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 6-amino-5-nitronicotinate (9.0 g, 46 mmol) and a small amount of Pd/C cat. were added to methanol (200 ml) and the mixture was hydrogenated at room temperature and atmospheric pressure until the uptake of hydrogen ceased. Following filtration through celite, the methanol was evaporated under reduced pressure to give the title compound, 7.0 g (92%).

Aufarbeitung

  1. customwas hydrogenated at room temperature
  2. filtrationfiltration through celite
  3. customthe methanol was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-02d92824d41e468fa86f2ba63b09f304
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313137B1

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