Water → 2-(2-Bromo-3-methylphenyl)acetic acid
Reaktionsgleichung
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]#N.S(=O)(=O)(O)[OH:13].[OH2:17]>>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:13])=[O:17]Komponenten
4
Versuchsvorschrift
2-(2-bromo-3-methylphenyl)acetonitril (8.0 g, 0.038 mol) was added to a mixture of water (60 ml) and sulfuric acid (50 ml) and the mixture was refluxed overnight. After cooling to room temperature water (200 ml) was added and the mixture was extracted twice with methylene chloride. The methylene chloride extracts were combined, washed twice with water, dried and evaporated under reduced pressure to give 7.9 g (90.8%) of the title compound.
Aufarbeitung
- temperaturethe mixture was refluxed overnight
- additionwas added
- extractionthe mixture was extracted twice with methylene chloride
- washwashed twice with water
- customdried
- customevaporated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-fdfacd031197455d85cf1bcf8b4c8f00
- Quelldatensatz
- uspto-grants-2001_11
- Patentnummer
- US06313137B1
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