Ethylamine → 6-(Ethylamino)pyridine-3-carboxylic acid
Reaktionsgleichung
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[CH3:12]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 170 °C
Versuchsvorschrift
6-Chloronicotinic acid (100 g, 0.63 mol) was treated with ethylamine (70% in water, 500 ml). The reaction was sealed in an autoclave and heated to 170° C. for 6 hours. The reaction mixture was evaporated, partially neutralised with concentrated HCl and the pH adjusted to 5 with glacial acetic acid. The solid product was filtered off and dried in vacuo for 18 hours to give 6-(ethylamino)nicotinic acid (87.8 g, 84%).
Aufarbeitung
- customThe reaction was sealed in an autoclave
- customThe reaction mixture was evaporated
- filtrationThe solid product was filtered off
- customdried in vacuo for 18 hours
Quellen und Nachweise
- ORD-Eintrag
- ord-7fe7c95260d642129e724b2c4f9e797d
- Quelldatensatz
- uspto-grants-2001_11
- Patentnummer
- US06313148B1
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