Nitrogen → 1-(4-Chloromethyl-thiazol-2-yl)ethanone

HRID 42796

Reaktionsgleichung

Reaktionsgleichung von HRID 42796
N#N.[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH:10]([OH:12])[CH3:11])[S:8][CH:9]=1>C(C#N)(C)=O.O=[Mn]=O>[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([C:10](=[O:12])[CH3:11])[S:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 947NitrogenHCID 668198411-(4-Chloromethyl-thiazol-2-yl)-ethanol

Produkt 1

HCID 668199771-(4-Chloromethyl-thiazol-2-yl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 694302-OxopropiononitrileLösungsmittel

Versuchsvorschrift

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(4-chloromethyl-thiazol-2-yl)-ethanol (1.09 g, 6.15 mmol) in AcCN (61.0 mL) was treated at rt with MnO2 (2.97 g, 30.76 mmol) and the reaction mixture was stirred for 16 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.84 min, [M+H]+=176.41.

Aufarbeitung

  1. filtrationbefore being filtered through Celite
  2. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-182df11f68794eaba278d087ecf90f25
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536209B2

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