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Water → HCID 18357788, Verbindung

HRID 427985
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 427985
[H-].[Na+].[CH3:3][C:4]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:5]=1[O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([OH:19])[C:15]([O:17][CH3:18])=[O:16].[CH3:25]I.O>CN(C)C=O>[CH3:3][C:4]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:5]=1[O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([O:19][CH3:25])[C:15]([O:17][CH3:18])=[O:16].[CH3:3][C:4]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:5]=1[O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([OH:19])[C:15]([O:17][CH3:18])=[O:16]
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Komponenten

7

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 18357788HCID 18357788, Verbindung

Produkt 2

HCID 11781996HCID 11781996, VerbindungHCID 18357788HCID 18357788, VerbindungAusbeute 191,4 %

Reagenzien, Katalysatoren, Lösungsmittel

1
HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

60% oily sodium hydride (0.13 g, 3.3 mmol) was added to a solution of methyl 2-[2-(2,5-dimethylphenoxymethyl)-phenyl]-2-hydroxyacetate (0.72 g, 2.4 mmol) and methyl iodide (0.68 g, 4.8 mmol) in N,N-dimethylformamide (6 ml) at 0° C. with stirring. After 30 minutes, ice and water were added in this order, and the mixture was extracted with ethyl acetate, washed successively with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by column chromatography on silica gel (n-hexane/ethyl acetate=9/1) to give the desired compound methyl 2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-hydroxyacetate (0.69 g, 92%) as an oil.

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. washwashed successively with water and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated
  5. customthe residue was purified by column chromatography on silica gel (n-hexane/ethyl acetate=9/1)

Quellen und Nachweise

ORD-Eintrag
ord-d9d47b05693345d096b01108040c9a0e
Quelldatensatz
uspto-grants-2001_11
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06313150B1

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