Triethylamine → HCID 13601222, Verbindung

Temperatur

-16 °C

A solution of 2.5 g (12.13 mmol) of the acid obtained in Step A in 30 ml of anhydrous tetrahydrofuran is cooled to −16° C.; 2.5 ml (18.2 mmol) of triethylamine are then added dropwise to the medium. After 10 minutes of stirring, 1.98 g (18.2 mmol) of ethyl chloroformate are slowly added to the reaction mixture. The solution is stirred under argon for 3 hours, the salts are filtered off and then the filtrate is cooled to −16° C. 1.84 g (48.5 mmol) of sodium borohydride are added to the medium all at once; 10 ml of methanol are then added very slowly to the solution. After 2 hours of stirring at −16° C., the reaction mixture is hydrolysed with a saturated solution of ammonium chloride; the aqueous phase is then extracted with ethyl acetate. The organic phase, dried over magnesium sulphate and then filtered, is concentrated under reduced pressure. The allyl alcohol of the title is obtained pure in the form of a yellow oil after passage over a silica column (eluant:AcOEt/PE:30/70 then 50/50).

1. stirringThe solution is stirred under argon for 3 hours
2. filtrationthe salts are filtered off
3. stirringAfter 2 hours of stirring at −16° C.
4. extractionthe aqueous phase is then extracted with ethyl acetate
5. dry with materialThe organic phase, dried over magnesium sulphate
6. filtrationfiltered
7. concentrationis concentrated under reduced pressure

ORD-Eintrag

ord-f33fbfcc578a41299c632f16c964dcc0

Quelldatensatz

uspto-grants-2001_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06313160B1