Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate → 6-Trifluoromethyloxindole

HRID 428253

Reaktionsgleichung

Reaktionsgleichung von HRID 428253
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[CH2:14][C:15]([O:17]C)=O)([O-])=O>[Pd]>[F:11][C:10]([F:13])([F:12])[C:8]1[CH:9]=[C:4]2[C:5]([CH2:14][C:15](=[O:17])[NH:1]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 83569Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

Produkt 1

HCID 6084876-Trifluoromethyloxindole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Methyl 2-nitro-4-trifluoromethylphenylacetate (26 mg) was hydrogenated over 10% palladium on carbon and then heated at 100° C. for 3 hours. The catalyst was removed by filtration and the solvent evaporated to give the title compound.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-0e1f4787658f409ca724c5042aa9230b
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313158B1

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