Water → 5-(2-Chloroethyl)Oxindole

HRID 428254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 428254
[Cl:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=O.C([SiH](CC)CC)C.O>FC(F)(F)C(O)=O>[Cl:1][CH2:2][CH2:3][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2

Komponenten

5

Edukt 3

HCID 962WaterHCID 12052TriethylsilaneHCID 20605765-(Chloroacetyl)-1,3-dihydro-2H-indol-2-one

Produkt 1

HCID 145813925-(2-Chloroethyl)OxindoleAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

5-Chloroacetyl-2-oxindole(4.18 g) in 30 mL of trifluoroacetic acid in an ice bath was treated with 4.65 g of triethylsilane and stirred at room temperature for 3 hours. The mixture was poured into 150 mL of water and the precipitate collected by vacuum filtration, washed with 50 mL of water and dried to give 2.53 g (65% yield) of 5-(2-chloroethyl)-2-oxindole as a reddish-brown solid.

Aufarbeitung

  1. filtrationthe precipitate collected by vacuum filtration
  2. washwashed with 50 mL of water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-73c7bd99807c47bbb53c5d490f218ea1
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313158B1

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