3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one → HCID 178486575, Verbindung

HRID 428617

Reaktionsgleichung

Reaktionsgleichung von HRID 428617
C([N:8]1[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:10]1[CH:11]=[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)[N:8]=[CH:9]1

Komponenten

4

Edukt 1

HCID 184052653-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one

Produkt 1

HCID 178486575HCID 178486575, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one (1.1 g) is dissolved in ethanol (90 ml). The reaction solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst for 7 hours. The mixture is filtered to remove the catalyst, and the filtrate is evaporated under reduced pressure. The product is converted to its hydrochloride salt in ethyl acetate using dry hydrochloric acid. The yield is 0.6 g, m.p. 258-261° C.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ee120878f08745b19a7414a1108d4a3f
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313311B1

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