Pyridine → HCID 22141268, Verbindung

HRID 428972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 428972
O[CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)[C:3]#[N:4].N1C=CC=CC=1.S(Cl)([Cl:22])=O>C(OCC)C>[Cl:22][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)[C:3]#[N:4]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 32778082-Hydroxy-2-(3-nitrophenyl)acetonitrile

Produkt 1

HCID 22141268HCID 22141268, VerbindungAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 2-hydroxy-2-(3-nitrophenyl)acetonitrile (Preparation 113, 1.0 g, 5.62 mmol) in diethyl ether (10 ml) was stirred at room temperature and treated with pyridine (0.1 ml, 1.24 mmol) followed by thionyl chloride (0.82 ml, 11.2 mmol) dropwise over 5 minutes. The mixture was gently heated under reflux and after 30 min the solvent was removed by evaporation to give a pale yellow solid. This was purified by column chromatography on silica gel eluting with hexane:ethyl acetate (3:1 and then 2:1) to give the title compound as a white crystalline solid (980 mg, 89%).

Aufarbeitung

  1. temperatureThe mixture was gently heated
  2. temperatureunder reflux and after 30 min the solvent
  3. customwas removed by evaporation
  4. customto give a pale yellow solid
  5. customThis was purified by column chromatography on silica gel eluting with hexane:ethyl acetate (3:1

Quellen und Nachweise

ORD-Eintrag
ord-f1ca5067dba844f2bb60468c4c87d628
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313312B1

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