Hydromorphone Hydrochloride → Hydromorphone

HRID 429002

Reaktionsgleichung

Reaktionsgleichung von HRID 429002
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15].Cl>O.[O-2].[O-2].[Ti+4]>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15]

Komponenten

4

Edukt 1

HCID 5462347Hydromorphone Hydrochloride

Produkt 1

HCID 5284570Hydromorphone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 162651Titanium oxide (Ti3O)KatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

Hydromorphone beads were prepared by dissolving hydromorphone HCl in water, adding Opadry® Y-5-1442, light pink (a product commercially available from Coloron, West Point, Pa., which contains hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, polyethylene glycol and D&C Red No. 30 Aluminum Lake), 20% w/w, and mixing for about 1 hour, and then spraying onto nu pariel 18/20 beads using a Wurster insert. The resultant coated beads were then overcoated with Opadry® Y-5-1442 light pink (15% w/w). The resultant preparation had the formula set forth in Table 1 below:

Aufarbeitung

  1. additionadding Opadry® Y-5-1442
  2. additionmixing for about 1 hour
  3. customThe resultant preparation

Quellen und Nachweise

ORD-Eintrag
ord-70b09ec84c68476a83fb26cca84cff9f
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06316031B1

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