Triethylamine → 2-Phenyl-4-(2-methylphenyl)cyclohexanone oxime

HRID 429719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 429719
[C:1]1([CH:7]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])[CH2:10][CH2:9][C:8]2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.Cl.[NH2:29][OH:30]>CO.C(Cl)Cl>[C:1]1([CH:7]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])[CH2:10][CH2:9][C:8]2=[N:29][OH:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 18352673HCID 18352673, Verbindung

Produkt 1

HCID 867506802-Phenyl-4-(2-methylphenyl)cyclohexanone oximeAusbeute 59 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21226129Dichloromethane methanolLösungsmittel

Versuchsvorschrift

2-Phenyl-4-(2-methylphenyl)cyclohexanone, 13.1 grams (49.5 mmol), was dissolved in 200 mL methanol/methylene chloride, followed by 11.1 mL (79.3 mmol) triethylamine and 5.5 grams (79.3 mmol) hydroxylamine hydrochloride. The solution was stirred at room temperature for 48 hours, the solvent evaporated, and the resulting solid washed with methanol and dried to afford 8.2 grams (59%) of a yellow solid.

Aufarbeitung

  1. customthe solvent evaporated
  2. washthe resulting solid washed with methanol
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c21031604a664fc4a4ada417b0320005
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06319915B1

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