Methyl iodide → 8-(2-Chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide

HRID 4298

Reaktionsgleichung

Reaktionsgleichung von HRID 4298
[CH3:1][I:2].[Cl:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[CH2:6][O:7][C:8]1[C:9]2[N:10]([C:14]([CH2:18][N:19]([CH3:21])[CH3:20])=[C:15]([CH3:17])[N:16]=2)[CH:11]=[CH:12][CH:13]=1>CC(C)=O>[I-:2].[Cl:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[CH2:6][O:7][C:8]1[C:9]2[N:10]([C:14]([CH2:18][N+:19]([CH3:1])([CH3:21])[CH3:20])=[C:15]([CH3:17])[N:16]=2)[CH:11]=[CH:12][CH:13]=1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 138259368-(2-Chlorobenzyloxy)-3-dimethylaminomethyl-2-methylimidazo[1,2-a]pyridine

Produkt 1

HCID 138259378-(2-Chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodideAusbeute 101,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Methyl iodide (3.48 g) was added dropwise to a solution of 8-(2-chlorobenzyloxy)-3-dimethylaminomethyl-2-methylimidazo[1,2-a]pyridine (7.8 g) in acetone (100 ml) at room temperature and the mixture was stirred for 24 hours. The resulting precipitate was collected by filtration, washed with acetone, and dried in a desiccator to give 8-(2-chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide (11.35 g).

Aufarbeitung

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with acetone
  3. customdried in a desiccator

Quellen und Nachweise

ORD-Eintrag
ord-91c2eee7c15b45b0a59d06a37df37e76
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04725601

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