Phosgen toluene → HCID 86757603, Verbindung

HRID 429828

Reaktionsgleichung

Reaktionsgleichung von HRID 429828
[C:1]([Cl:4])([Cl:3])=[O:2].C1(C)C=CC=CC=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([CH2:23][CH2:24][NH:25][CH2:26][CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)([CH3:22])[CH3:21])=[CH:16][CH:15]=1>C(OCC)C>[ClH:3].[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]([CH2:23][CH2:24][NH:25][CH2:26][CH:27]2[CH2:32][CH2:31][N:30]([C:1]([Cl:4])=[O:2])[CH2:29][CH2:28]2)([CH3:21])[CH3:22])=[CH:18][CH:19]=1

Komponenten

4

Edukt 2

HCID 19083224Phosgen tolueneHCID 86757605HCID 86757605, Verbindung

Produkt 1

HCID 86757603HCID 86757603, VerbindungAusbeute 77,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of 2 M phosgene/toluene (2.0 ml, 4 mmole) in ethyl ether (20 ml) was added a solution of N-[2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine (0.23 grams, 0.79 mmole) in ethyl ether (30 ml). After 30 minutes the precipitate was collected by filtration and dried in vacuo to give N-[2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(1-chlorocarbonylpiperidin-4-ylmethyl)amine hydrochloride (0.238 grams, 77%), m.p. 144-145° C.

Aufarbeitung

  1. filtrationAfter 30 minutes the precipitate was collected by filtration
  2. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1ec6e23dc6ff4907bd35a8ee02bb9891
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06319920B1

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