Potassium cyanate → N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(1-aminocarbonylpiperidin-4-ylmethyl)amine

HRID 429830Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 429830
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([N:13]([CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH2:14][CH3:15])[CH3:12])=[CH:6][CH:5]=1.[O-:23][C:24]#[N:25].[K+]>O>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH:11]([N:13]([CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([C:24]([NH2:25])=[O:23])[CH2:19][CH2:18]2)[CH2:14][CH3:15])[CH3:12])=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 11378442Potassium cyanateHCID 18352897N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine hydrochloride

Produkt 1

HCID 18352825N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(1-aminocarbonylpiperidin-4-ylmethyl)amineAusbeute 77,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine hydrochloride (0.42 grams, 1.16 mmole) and potassium cyanate (1.5 grams, 18.5 mmole) in water (5 ml) was heated under reflux for about 20 minutes. The white solid which formed upon cooling was collected and recrystallized from chloroform/hexane to give N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(1-aminocarbonylpiperidin-4-ylmethyl)amine (0.3 grams, 77%), m.p. 104-10° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for about 20 minutes
  3. customThe white solid which formed
  4. temperatureupon cooling
  5. customwas collected
  6. customrecrystallized from chloroform/hexane

Quellen und Nachweise

ORD-Eintrag
ord-4b7bf7587c4d4c43a61ba5b87f1779a9
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06319920B1

Notizen zur Reaktion

Wird geladen…