2,4-Di-tert-butylphenol → 2-Bromo-4,6-di-tert-butylphenol

HRID 429945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 429945
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[Br:16]Br>>[Br:16][C:7]1[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15]

Komponenten

3

Edukt 2

HCID 73112,4-Di-tert-butylphenolHCID 24408Bromine

Produkt 1

HCID 5198222-Bromo-4,6-di-tert-butylphenolAusbeute 91,8 %

Versuchsvorschrift

To a solution of 2,4-di-t-butylphenol (Aldrich, 2.0 g, 9.7 mmol) in 2 ml of HOAC was added Br2 (0.5 ml, 9.7 mmol). The reaction mixture was stirred at room temperature for 12 hours. Solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate/hexane 1/20) to yield the desired product (2.54 g) as a white solid.

Aufarbeitung

  1. customSolvent was removed under reduced pressure
  2. customthe residue was purified by column chromatography (ethyl acetate/hexane 1/20)

Quellen und Nachweise

ORD-Eintrag
ord-7fed9cd228f34ef19a46051c6ee2e031
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06320047B1

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