3-(2,4-Dichlorophenyl)propanoic acid → 4,6-Dichloro-1-indanone

HRID 430070

Reaktionsgleichung

Reaktionsgleichung von HRID 430070
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([OH:13])=O>O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]2[C:3]=1[CH2:9][CH2:10][C:11]2=[O:13]

Komponenten

3

Edukt 1

HCID 27409153-(2,4-Dichlorophenyl)propanoic acid

Produkt 1

HCID 122065184,6-Dichloro-1-indanoneAusbeute 4,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

3-(2,4-dichlorophenyl)propanoic acid (0.44 g, 2 mmol) in polyphosphoric acid (7 g) was heated to 100° C. under argon. After 90 min the mixture was cooled and treated with water (20 ml) and extracted with hexane (40 ml). The hexane layer was dried (MgSO4), and evaporated to dryness. The residue was purified by column chromatography on silica gel eluting with 0-30% dichloromethane in hexane to give the title product as a yellow solid, (0.018 g, 4.5%), δH (CDCl3) 2.8 (2H, m), 3.1 (2H, m), 7.6 (1H, d), 7.65 (1H, d).

Aufarbeitung

  1. temperatureAfter 90 min the mixture was cooled
  2. extractionextracted with hexane (40 ml)
  3. dry with materialThe hexane layer was dried (MgSO4)
  4. customevaporated to dryness
  5. customThe residue was purified by column chromatography on silica gel eluting with 0-30% dichloromethane in hexane

Quellen und Nachweise

ORD-Eintrag
ord-bdaed1af101f4a3fb37531108d241fdc
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06320051B1

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